Hey Jonah! I completely agree that while another global flu epidemic is possible, it is highly unlikely, and it definitely would not be as catastrophic as the 1918 epidemic. We have so many vaccines and treatments now, and people are much more educated on disease transmission and safety measures to combat the spread of disease. I think it is interesting that you think the “Next Big One” could be a bioterrorist attack. I think it could definitely be possible. The thing about it being a bioterrorist attack is that the intention would be to kill people, so the fatality rate would probably be significantly higher. A mutated form of smallpox would be devastating, and despite modern medical advancements, it would be very difficult to control. It is pretty scary to think about.