https://medicalxpress.com/news/2019-02-crisprcas9-therapy-suppress-aging.html
As one gets older, health issues occur. These health issues could range from being off-balance, high blood pressure, or something more serious, like cancer. With the effects of getting older, anti-aging therapy is coveted by many. CRISPR/Cas9 therapy can suppress accelerated aging in mice, so eventually, it will be able to help humans. This therapy reduces toxic proteins through gene therapy. Two months after the mice were tested, they appeared stronger and more active with improved cardiovascular health; their life span increased by 25%.
Progeria, or AKA, Hutchinson-Guilford progeria syndrome, is a premature aging disease and is extremely rare. Mice with this syndrome were treated with CRISPR-Cas9 therapy. An Adeno-associated virus was injected into the mice, which contained two synthetic guide RNAs and a reporter gene to deliver the Cas9 protein to a specific location on the DNA; this would help track the tissue infected with AAV (adeno- associated viruses.)
Scientists at Harvard’s Wyss Institute for Biologically Inspired Engineering have used a combination of three longevity-associated genes delivered by one injection to improve or reverse multiple age-related diseases in mice. A Wyss core faculty member, stated, “gene therapy gives you a testable therapy at scale in mice. And we can move from mice to dogs and then to humans. We’re focusing on the reversal of age-related diseases so we’ll be more healthy and youthful later in life.”