1. Manual labor, poverty, safety/public health, and economic systems have become influencers of entrepreneurship throughout history. Technology and organizations have upgraded, making production much easier and profitable than years before.
2. If I were to create a functioning permaculture garden, I could see manual labor and safety impacting my opportunities. I would need man power to create multiple closed-loop systems, nutrient dispersal, water retention banks, etc. Doing this by myself would be an undertaking. Once I bring on a workforce, their safety will be put at risk by possible injuries or spread of viruses.